Intriguingly, there is a splicing variant for TMIGD3 i1 that shares the first exon (A1), which is well characterized as A3AR, one of the four adenosine receptors with a typical seven-transmembrane helical structure of a GPCR and is implicated in the suppression of several cancers and autoinflammatory diseases16. This evidence concerns the gene ADORA3 and cancer.