FANCF and systemic lupus erythematosus: Surprisingly, only three mRNAs were downregulated in both groups—the 3′-exonucleases TREX1 and TREX2 and the fanconi anaemia complementation group F gene, FANCF. Mutations in TREX1 have been associated with several human diseases including systemic lupus erythematosus and retinal vasculopathy with cerebral leukodystrophy (RVCL)16, 17, 18.