Indeed, the expression signature of stem cell26, 27, 28 or targets of Nanog, Oct4, Sox2 and c-Myc (NOSM) in human ESCs29, 30, 31 were significantly enriched in our mRNA profile of sunitinib-resistant RCC cells (GSE69535) (Supplementary Fig. 1a), prompting us to explore the role of lncARSR in renal T-ICs. Here, LNCARSR is linked to renal cell carcinoma.