EGFR and head and neck squamous cell carcinoma: These data suggest that inhibition of the migratory potential of HNSCC cells by GSPs involves the: (i) inhibitory effect of GSPs on EGFR overexpression; (ii) inhibitory effect of GSPs on the activation of the ERK1/2 proteins and inactivation of NF-κB; and (iii) reversal of the EMT, as summarized in Figure 2 and Figure 3.