CASP3 and neoplasm: Singh et al. [51] found that the inhibitory effects of honokiol on tumor xenograft growth that they observed were associated with the: (i) Inhibition of PCNA, and correction of dysregulation of proteins associated with cell cycle progression; (ii) Induction of apoptotic cell death of tumor cells, as indicated by increased levels of activated caspase-3; and (iii) reduction in the levels of EGFR, pAkt and mTOR ([53], and Figure 2).