Preclinical studies with adoptive cell transfer (ACT) of T cells expressing chimeric antigen receptors (CAR) against mesothelin (MSLN), a tumor antigen associated with decreased survival and overexpressed on the surfaces of more than 90% of epithelioid malignant pleural mesothelioma, resulted in enhanced T cell recruitment towards MSLN+ cells and a 2- to 5-fold increase in Th1 cytokine secretion. The gene discussed is MSLN; the disease is malignant pleural mesothelioma.