Cationic dextran and polyethyleneimine repolarized MDSCs of 4T1 tumor bearing mice into anti-tumor cells to express tumoricidal cytokines (IL-12, TNF-α) with less production of immunosuppressive factors (IL-10, TGF-β) reactivating T-cell functions which resulted in reduced tumor growth and prolonged survival [176]. Here, TNF is linked to neoplasm.