Another inhibitor of JAK1 and STAT3, a synthetic triterpenoid, bardoxolone methyl (C-28 methyl ester of 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid, also known as CDDO-Me) abrogated the immune suppressive effect of MDSCs on CD8+ cytotoxic T-cells resulting in decreased tumor growth in mice [162,163]. The gene discussed is CD8A; the disease is neoplasm.