It has been reported the nucleoside analog, conventional chemotherapeutical agent gemcitabine caused apoptosis and necrosis of splenocytes, selectively reduced the expansion of Gr1+/CD11b+ splenic MDSCs preserving CD4+ and CD8+ T-cells and that was accompanied by augmented antitumor activity of CD8+ T-cells and enhanced IFN-β gene delivery in murine mesothelioma [138]. This evidence concerns the gene CD8A and mesothelioma.