As shown in Figure S5, EpCAM ALB aptamers were able to bind to the two different types of human cancer cell lines, but they did not bind to normal cell line (HEK-293T), indicating that the aptamers selected against recombinant EpCAM protein can also recognize the native EpCAM protein on live cell membranes (data not shown). The gene discussed is EPCAM; the disease is cancer.