Most recently, SASH1 is showed to be involved in autosomal‐dominant lentiginous 26 and autosomal‐recessive SASH1 variants (c.1849G>A; p.Glu617Lys) which are associated with a new genodermatosis with a pigmentation defects, palmoplantar keratoderma and skin carcinoma, and SASH1 is firstly reported to be predisposed to skin cancer 27. The gene discussed is SASH1; the disease is Palmoplantar keratoderma.