This study in patients with uncomplicated mild-to-moderate hypertension compared the effects of reducing noradrenergic sympathetic vascular tone by the alpha 1-adrenoceptor blocker doxazosin to blocking the RAAS by the ACE inhibitor ramipril to assess the possible influence of the RAAS on vascular structure and function beyond the effects on blood pressure. The gene discussed is ACE; the disease is Hypertension.