In hypertensive patients with established coronary artery disease, suggesting more advanced atherosclerotic vascular disease, the ACE inhibitor quinapril, but not enalapril or the angiotensin receptor blocker losartan, improved endothelial function [45], whereas ramipril seemed to improve FMD in hypertensive patients in a dose-dependent manner [46]. The gene discussed is ACE; the disease is coronary artery disorder.