CTE is classified as a tauopathy, yet a subset of reported cases displays diffuse or neuritic β-amyloid plaques in cortical gray matter, which instigated the debate decades ago concerning the pathophysiologic connections among head injury, neuropathological neurodegenerative indicators such as p-tau and β-amyloid protein accumulations and augmented development of neurodegenerative diseases. This evidence concerns the gene MAPT and amyloidosis.