BCL2 and neoplasm: Several previous studies have revealed that BCL2 is a target of several miRNAs, such as miR-30e which downregulates BCL2 gene expression to promote apoptosis through the cleavage of caspases18, and miR-34a which inhibits BCL2 gene expression to induce sensitivity to the anti-tumour effect of sorafenib in human HCC cells20.