In addition, despite it has been well documented that obesity cause insulin resistance, which is involved in the pathogenesis of NAFLD, here we found that the participants with a 1-SD increase in circulating periostin showed a 1.75 times risk for NAFLD, no matter the degree of insulin resistance, indicating that alone an increased periostin concentrations could augment the NAFLD phenotype by the mechanisms differ from insulin resistance. Here, POSTN is linked to Obesity.