WGS of the parent–child trio identified a heterozygous de novo mutation (c.40G>A encoding p.V14I) in KRAS, which has been reported previously in patients with Noonan syndrome.36 In the light of the exome results, an echocardiogram was performed, which was normal at almost 3 years of age, but she will continue cardiac surveillance. Here, KRAS is linked to Noonan syndrome.