The relationships between AGA and asparagine (Pdis = 1.3 × 10−10, Prep = 2.7 × 10−5), dimethylglycine and DMGDH (Pdis = 3.2 × 10−31, Prep = 8.1 × 10−12), N-acetylalanine, N-acetylthreonine and ACY1 (Pdis = 4.1 × 10−41 and 1.1 × 10−10, Prep = 3.9 × 10−15 and 4.7 × 10−5), proline and PRODH (Pdis = 1.4 × 10−29, Prep = 1.5 × 10−11) are consistent with known autosomal recessive metabolic disorders. The gene discussed is PRODH; the disease is metabolic disease.