A marked dose-dependent decrease in viability of all CML cell lines was observed in response to treatment with NiPT (Fig. 1a), with 50% inhibitory concentration (IC50) values of 0.14, 0.17, 0.3, 0.16, and 0.98 μM in KBM5, KBM5R, BaF3-p210-WT, BaF3-p210-T315I, and K562 cells, respectively. This evidence concerns the gene EVPL and chronic myelogenous leukemia, BCR-ABL1 positive.