HAS1 and neoplasm: To determine the abundance of HAS isoforms in CAFs from OSCCs and the paired NFs from the same patients, fresh OSCC samples were acquired from three patients by macroscopic dissection using the following morphological mapping: CAFs from the actual tumors were isolated from the epicenter of the tumor tissue, and the matched NFs were isolated from distal normal tissue located at least 10 mm from the tumor margins.