ARHGEF4 and cancer: By checking the gene list manually, we found several cancer related genes integrated by HPV either in the intron or 5’ flanking region (Table 5), they were TNFSF4 (tumor necrosis factor superfamily member 4), TP63 (tumor protein p63), TP73 (tumor protein p73), ARHGEF4 (Rho guanine nucleotide exchange factor 4), CDH13 (cadherin 13), RASSF6 (Ras association domain family member 6) [17–30].