It is believed that inhibition of LOX and COX pathways and administration of anti-inflammatory compounds may be of benefit in type 2 DM especially in preventing long-term complications of DM especially those related to inflammatory and oxidative stress related complications that are generally mediated by IL-6, tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2, derived from arachidonic acid), reactive oxygen species (ROS) and other related molecules. This evidence concerns the gene TNF and diabetes mellitus.