Additionally, genetic studies of QRS duration [75], which has been associated with increased risk of heart failure [76, 77], indicate a role of LRIG1. In our study, methylation at this gene associated with HCY, an amino acid previously associated with inflammation in blood vessels, progression to atherosclerosis and development of CVD, particularly ischemic stroke [11, 12]. This evidence concerns the gene LRIG1 and atherosclerosis.