Overexpression of EGFR and of its ligands TGF-α or EGF has been observed in about 90% of SCCHN specimens, with the exception of HPV-positive tumors, and correlates with poor disease-free and overall survival, an increased risk of disease recurrence and metastasis, and resistance to chemotherapy, including cisplatin, and radiotherapy [22]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.