Actually, several oncoproteins or tumor suppressors have been proven to be implicated in the control of protein synthesis through the transcriptional regulation of ribosomal proteins so as to affect tumorigenesis or progression of cancer6, 31, 42, and of particular note among those TFs identified in our study is MYC, a well characterised oncogene43, enhanced expression or amplification of which has been reported in numerous cancer types, including OS44. The gene discussed is MYC; the disease is cancer.