Notably, interactions between β-HCH and rs182052 demonstrated significantly increased risk of T2DM (OR = 2.20, 95% CI: 1.39–3.49), which was consistent with the combined effect of β-HCH and rs182052 on decreased levels of plasma adiponectin (8.04 μg/mL), a common predictor of diabetes. Here, ADIPOQ is linked to type 2 diabetes mellitus.