Genes in this signature code for proteins that are viral infection restricting factors (e.g. Ifitm1, Ifitm3, Gbp7), that protect against cellular or environmental stress (e.g. Abcb1a, Car2, Ern1, Serpina3g) or that regulate immune activation processes (e.g. Fgl2, Anxa1, Havcr2). The gene discussed is ERN1; the disease is viral infectious disease.