Many cancer cell lines express adiponectin receptors, so adiponectin limits cancer cell proliferation and induce apoptosis.5, 45, 46 However, adiponectin also inhibits apoptosis of cardiac cells, mesenchymal stem cells and auditory hair cells.47, 48, 49 Thus, the ability of adiponectin to mediate an alternative function in cell apoptosis provides an attractive hypothesis to explain its protective effects in apoptosis of adipocytes. Here, ADIPOQ is linked to cancer.