The pathological features of PD comprise of widespread degeneration of dopaminergic neurons and aggregation of Lewy bodies and cytoplasm inclusion bodies of α-synuclein.82 Interestingly, similar to the spread of pathogenic tau and Aβ proteins, EVs also have crucial roles in the aggregation and the spread of α-synuclein, thereby propagating disease pathogenesis in PD.83, 84, 85. This evidence concerns the gene MAPT and Parkinson disease.