Some apoptosis-related genes have been identified as miR-143 targets in multiple cell types, such as BCL-2 in gastric cancer cells45 and osteosarcoma cells,44 BAG3 (BCL-2-associated athanogene 3) in glioblastoma stem cells,46 and FSCN1 in esophageal squamous cell carcinoma.47 However, the role of miR-143 in GC apoptosis remains unknown. The gene discussed is BCL2; the disease is esophageal squamous cell carcinoma.