At 4 days post fertilization (d.p.f.), the mdm2 KD zebrafish larvae developed pericardial edema (white arrow in Figure 2b), a hallmark of kidney failure, in contrast to control morpholino-injected larvae (Ctrl) and larvae with a double KD knockout of mdm2 and p53 (mdm2/p53). This evidence concerns the gene TP53 and kidney failure.