SMPD3 and osteochondrodysplasia: Our studies delineate a novel function of SMPD3 in the lipid-driven formation of vesicle carriers in the GSP during growth and development, and provide insight into the molecular pathology of SMPD3 deficiency leading to an unprecedented mechanism of growth inhibition and to retarded development, manifested juvenile dwarfism and osteochondrodysplasia.