Further analysis showed that EZH2 expression positively correlated with tumor pathological differentiation grades, with much higher expression in grades III/IV (more poorly differentiated) than that of grades I/II (91.1% versus 8.9%, respectively, P<0.05) (Figure 1c), whereas being independent of age, tumor size and TNM stage (Supplementary Table 1). The gene discussed is EZH2; the disease is neoplasm.