EZH2 and cancer: Some reports indicate EZH2 knockdown may affect DNA damage response by abrogating cell cycle checkpoints and reducing DNA double-strand break repair, therefore sensitizing the cells to cancer therapy,41, 42 whereas others show depletion of EZH2 results in enhanced DNA damage repair because of elevated expression of DNA damage repair genes.43, 44, 45 Apparently, more work has to be done to prove the regulatory role of EZH2 in LDM-induced DNA damage responses.