TP53 and cancer: Consistently, epigenetic regulation of p21 by EZH2 regardless of p53 status is reported in other cancer types during senescence induction.23, 34 Furthermore, given LDM-caused p21 induction could not be totally reduced by EZH2 overexpression in HCT116 cells (Figure 6b), some p53-dependent regulation of p21 may not be excluded in the cells harboring wild-type p53.36