IL-1r−/− developed hyperglycemia and lower insulin levels in response to streptozotocin (unpaired t-test; P=0.0001 and P=0.04 respectively; Supplementary Table 3; Fig. 7b), but in the absence of IL-1r no prolongation of QT (Supplementary Fig. 11a) and QTc intervals after DM induction (Fig. 7c) could be observed. The gene discussed is INS; the disease is diabetes mellitus.