Our data are compatible with the rs4487645 G-allele, conferring an increased MM risk through increased IRF4-mediated expression of CDCA7L. Furthermore, epigenetic and 3C data are consistent with rs4487645 localizing within a chromatin contact domain and forming a ‘loop domain', which is expected to bring the region into physical contact with the promoter of CDCA7L. Mechanistically, our data also provide linkage between the G-risk allele, which is associated with higher expression of CDCA7L in MM, with effects on cell proliferation and response to apoptosis. This evidence concerns the gene IRF4 and Miyoshi myopathy.