To demonstrate the in vivo inhibition of VEGF expression and the antitumour efficacy of this strategy, the mixture of sgc4f and sgc8c aptamers was first intratumorally injected into mice bearing CEM xenograft tumour for 30 min, and siRNA-ONV, NCsiRNA-ONV, reaction buffer, siRNA-Lipo2000 and siRNA-TKO were then intratumorally injected into these mice, respectively. This evidence concerns the gene VEGFA and neoplasm.