PIK3R4 and Kidney Cyst: To assess the specificity of the morpholino effects and test the patient VPS15-R998Q missense mutation, we determined whether the vps15-mo phenotypes associated with cilia dysfunctions (body axis curvature and kidney cysts) could be rescued by co-injection of a synthetic zvps15 or zvps15-R976Q mutant mRNA (Fig. 3c,f).