TP53 and Complex Cyst of Kidney: We also observed the presence of kidney cysts as well as a cystic dilatation of the region slightly posterior to the ear at the level of the pectoral fin in 61% of vps15 morphants (Fig. 3d,e and Supplementary Fig. 3E), a phenotype not due to activation of p53-mediated apoptosis (Fig. 3e).