Findings were consistent when the same subgroup analysis was performed for only those p53 IHC studies with lower cut‐off value including pure ESCC cohorts (HR: 1.47, 95% CI: 1.29–1.69; P < 0.00001, n = 28, I2=28%; Fig. S4). The gene discussed is TP53; the disease is esophageal squamous cell carcinoma.