TGFB1 and neoplasm: Contrary to an observed antitumor effect and highlighting the dual role of ILC in tumor progression, studies with the 4T1 syngeneic murine model of human triple negative breast cancer have shown that endogenous IL-33, produced by tumor cells, was associated with increased frequencies of TGFβ-producing MDSC, regulatory T cells (Treg), and ILC2 that expressed IL-5 and IL-13 (Figure 2(b)).