In recent decades, COX-2 overexpression has been reported in several human cancers including breast [47–49], lung [47, 50], skin [51], colon [47, 52, 53], bone [32, 54, 55], cervical [56], oesophageal [57], pancreatic [58], prostate [59], and bladder cancer [60]. Here, PTGS2 is linked to cancer.