CASP3 and neoplasm: For example, in a mouse model of lung cancer, treatment with a caspase-3 inhibitor led to an increase in autophagy and radiosensitivity [116]; and treatment with a pan-caspase inhibitor, zVAD, or small interfering RNA directed against caspase-3 and caspase-7 led to radiosensitivity and delayed tumour growth rates, in breast and lung xenografts [117].