HIF-1α protein expression in tumor cells triggers malignant progression through various processes, including angiogenesis, which is achieved through VEGF; alterations in glucose metabolism, which is achieved through glucose transporter 1; tumor cell survival, which is achieved though insulin-like growth factor-1; and metastasis, which is achieved through lysyl oxidase and plasminogen activator inhibitor-1. The gene discussed is SERPINE1; the disease is neoplasm.