We hypothesize that whereas hyperinsulinemia may stimulate the development of antral follicles and recover the sensitivity of granulosa cells to FSH, therefore leading to increase in the number of follicles, ovarian volume, and AMH levels, myo-ins may improve clinical and hormonal features of PCOS patients by enhancing insulin sensitivity that decreases hyperinsulinemia. This evidence concerns the gene BRD2 and Hyperinsulinemia.