Many studies have found that IBD is closely related to the patients’ body immunity especially intestinal immune microenvironment.15 Previous studies have showed that IBD was an allergic inflammation induced by the imbalance of Th1/Th2 immune response, dominating with intestinal epithelial Th1 immune response.16 However in recent years, with in-depth study of CD4+T lymphocytes, the result found that the initial CD4+T cells could differentiate into different cells induced by the different cytokines. Here, CD4 is linked to inflammatory bowel disease.