The results of the study showed that compared with the healthy control group, the levels of IL-17, IL-23 and other cytokines in the peripheral blood of IBD patients were significantly increased, while the levels of IL-17, IL-23 and other cytokines were significantly down-regulated, which was consistent with the changes of Th17 and Treg proportions. The gene discussed is IL17A; the disease is inflammatory bowel disease.