VEGFA and neoplasm: A high prevalence of relapse is a restriction of TACE, likely due to the up regulation of VEGF and PDGFR, which sequentially increases tumor angiogenesis; therefore, the combination of TACE with antiangiogenic drugs has stranded out as an enhancement, aiming to decrease post-TACE angiogenesis and the incidence of metastatic disease and, as much as possible, improving loco-regional treatment efficiency.