FN1 and Hypertension: It has been shown that Fn1 gene expression correlates with cardiac remodeling induced by several factors such as volume overload (Plante et al., 2004; Konstandin et al., 2013), hypertension (Crawford et al., 1994) and myocardial infarction (Arslan et al., 2011) and most importantly, cardiomyocyte hypertrophy which is regulated via activation of Nuclear Factor of Activated T cells (NFAT; Konstandin et al., 2013).