RELA and Alzheimer disease: Although the majority of studies indicate elevations in NF-κB complexes, Kaltschmidt et al. (1999) also reported decreased nuclear localization of p65 in both neurons and glia surrounding mature plaques in cortical tissue in AD cortex relative to that from nondemented controls matched for age, post-mortem delay, and fixation time, suggesting reduced NF-κB activity associated with disease progression in AD.