SOD2 and Alzheimer disease: Despite these positive findings in mice in which MnSOD is manipulated genetically and the reported alterations to MnSOD in the AD brain, human genetic studies have failed to find a significant association between polymorphisms affecting MnSOD and AD risk (Ventriglia et al., 2005; Paz-Y-Miño et al., 2015; de Mendonca et al., 2016).