SOD2 and Alzheimer disease: In a study by Marcus et al. (2006), MnSOD protein levels, as detected by immunohistochemistry, was found to be highly elevated in multiple subfields (CA1, CA2/3, and CA4) of the hippocampus in AD relative to age-matched non-AD controls; however the lowest increase was seen in the CA1, where AD-related upregulation of MnSOD was significantly lower.