DLG4 and Alzheimer disease: In the 5xTg model, in which amyloid pathology is robust and early, Shao et al. (2011) found an age-dependent shift in PSD-95 localization from dendritic to somatic compartments in the hippocampus, confirming an aberrant subcellular distribution of this postsynaptically rich protein in association with AD-like neuropathology.