The present review will address NF-κB in the general context of learning and memory as it relates to the literature in AD, the devastating age-related dementia characterized by extracellular amyloid beta (Aβ) plaques, hyperphosphorylated-tau-containing neurofibrillary tangles (NFTs), severe loss of neurons, and cognitive deficits, particularly those related to memory. The gene discussed is MAPT; the disease is Alzheimer disease.