As circulating MCP-1 levels are increased in rodent obesity and the role of Forskolin in fat mass reduction is clearly established, the aim of this study was to determine on one hand the expression of MCP-1, TLR-4, GPR120, β-Arrestin 2, and NFκB1 expression in DC and on the other hand the signaling pathway by which Forskolin affects MCP-1 and GPR120 expression in the LPS-induced inflammatory response in 3T3-L1 cells differentiated into adipocytes. Here, TLR4 is linked to obesity due to melanocortin 4 receptor deficiency.