PROM1 and osteosarcoma: The results showed that the mRNA expressions of Bglap and adipoQ were more significantly increased in CD133+ cell subset, about 3~4 times than that in CD133- cell subset, and the difference was statistically significant (P < 0.05) (Fig. 9e, f), suggesting that the CD133+ cell subset had the significant differentiation potential of the characteristics of osteosarcoma of osteogenic and adipogenic.