IL10 and early-onset autosomal dominant Alzheimer disease: The detrimental effects of IL-10 in Alzheimer’s disease were further confirmed as IL-10 absence in a transgenic mouse model of cerebral amyloidosis resulted in amyloid-β phagocytosis by activated microglia and in reduced amyloid-β load in the mouse brains, which ultimately conferred a better outcome of the disease [80].