IL10 and multiple sclerosis: Importantly, in addition to the evidence placing IL-10 as a regulator of the immune crosstalk in the CNS, several studies directly implicate defective IL-10 production or signalling in patients and animal models of neurological diseases, ranging from neuropathic pain [48] to multiple sclerosis [49, 50], Alzheimer’s disease [51] or Parkinson’s disease [52].