It has been already proved that Cathepsin plays a crucial role in pathogenesis of different disorders of inflammation specifically rheumatoid arthritis (RA) whereas it may cause bone erosion and cartilage degradation in RA joints, increasing the activity of Cathepsin in synovial membranes involves potentially in cartilage degradation and bone destruction [59]. The gene discussed is CTSS; the disease is rheumatoid arthritis.