Since TP53-mutated KIRCs have a worse OS prognosis than TP53-wildtype KIRCs (Figure 6), TP53 lower-expression-level KIRCs should have a worse OS prognosis than TP53 higher-expression-level KIRCs if the association between TP53 expression and cancer prognosis correlates with TP53 mutation status. The gene discussed is TP53; the disease is cancer.