The other eight cancer types with a TP53 mutation rate that exceeds 50% include four gastro-intestinal cancers: esophageal carcinoma (ESCA), rectal adeno-carcinoma (READ), pancreatic adeno-carcinoma (PAAD) and colon adeno-carcinoma (COAD); two lung cancers: lung squamous-cell carcinoma (LUSC) and lung adeno-carcinoma (LUAD); and head-and-neck squamous-cell carcinoma (HNSC) and brain lower-grade glioma (LGG). The gene discussed is TP53; the disease is rectum adenocarcinoma.