We did not find significant differences in the TP53 mutation rates among different stages, T, N, or M status of tumor except that ACC shows a significantly higher TP53 mutation rate in large-size cancers (T3, T4) than small-size cancers (T1, T2) (unadjusted P-value = 0.04, odds ratio = 3.42). This evidence concerns the gene TP53 and cancer.