TP53 and cancer: Indeed, in nine of 31 cancer types analyzed, TP53 expression is significantly higher in TP53-mutated but TP53-non-truncating cancers than in TP53-wildtype cancers, and only in one cancer type is TP53 expression significantly lower in TP53-mutated but TP53-non-truncating cancers (P-value < 0.05, Supplementary Table S18).