MLH1 and neoplasm: Next, we conducted univariate and multivariate analyses using a Cox proportional hazards model to examine associations between sex, number of lymph nodes examined, pT4, lymphovascular invasion, tumor location, differentiation, KRAS mutations, MSI, and CIMP/MLH1 status (CIMP+/MLH1-U or other subtypes) and DFS and OS (Table 2).