Intriguingly, gain of methylation at mICRs (e.g., KCNQ1OT1, MEST, PLAGL1 and SNRPN) and loss of methylation at pICRs (e.g., H19) are frequently observed in spermatozoa from infertile human patients [28, 29]. The gene discussed is PLAGL1; the disease is Infertility.