CAPN1 and Sepsis: Similarly, the protein levels of Pa28β is increased by approximately 15% in the group (SSI) when compared to the sham group (SHAM) (0.71±0.06 vs. 0.62±0.05), where Pa28β levels remained similar in septic group treated with ALLN (SSI+ALLN) compared to the SHAM values (Fig 2C), suggesting a correlation between increased calpain-1 and ubiquitin-proteasome protein levels during sepsis.