Cardiac myocytes of dystrophin-deficient mdx mice are abnormally vulnerable to mechanical stress and sarcolemmal injury accompanied by decreased systolic and diastolic left ventricular dysfunction [31], suggesting that dystrophin disruption could be associated with the progression of cardiomyopathy as a result of mechanical stress and damage induced by the overload [32,33]. This evidence concerns the gene DMD and cardiomyopathy.